CERAD, The Consortium to Establish a Registry for Alzheimer’s Disease
CERAD Family History Assesment

In response to the need for a uniform family history assessment in genetic and epidemiological studies of AD, CERAD developed a standardized Family History Assessment of AD. This assessment consists of interview instruments, coding forms, and hierarchical rating systems designed to determine the presence of AD, Parkinson’s disease, and Down syndrome among relatives of cases of AD and their spouse controls.

These instruments are relatively brief (taking about 45 minutes to complete) and easy to administer.

This assessment was used in a multi-center family history study of AD to evaluate 118 cases with AD and their non-demented spouses, enrolled at 11 different CERAD sites in the US. The study found that first-degree relatives of patients with AD had a significantly greater cumulative risk of AD than did the relatives of spouse controls. Furthermore, the cumulative risk of AD was significantly greater among female relatives than among male relatives. The numbers of affected first-degree relatives with Parkinson’s disease or Down syndrome did not differ between the families of cases and those of controls.

See the CERAD list of publications on Family History.

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Center for the Study of Aging and Human Development, Duke University Medical Center

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