In response to the need for a uniform family history assessment
in genetic and epidemiological studies of AD, CERAD developed
a standardized Family History Assessment of AD. This assessment
consists of interview instruments, coding forms, and hierarchical
rating systems designed to determine the presence of AD,
Parkinson’s disease, and Down syndrome among relatives
of cases of AD and their spouse controls.
These instruments are relatively brief (taking about 45
minutes to complete) and easy to administer.
This assessment was used in a multi-center family history
study of AD to evaluate 118 cases with AD and their non-demented
spouses, enrolled at 11 different CERAD sites in the US.
The study found that first-degree relatives of patients with
AD had a significantly greater cumulative risk of AD than
did the relatives of spouse controls. Furthermore, the cumulative
risk of AD was significantly greater among female relatives
than among male relatives. The numbers of affected first-degree
relatives with Parkinson’s disease or Down syndrome
did not differ between the families of cases and those of
See the CERAD list of publications on Family History.
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